公开(公告)号：US20110158985A1

公开(公告)日：2011-06-30

申请号：US12969514

申请日：2010-12-15

申请人： GENEVIEVE LOSONSKY ,  EDWARD M. CONNOR ,  JAMES F. YOUNG ,  HERREN WU ,  WILLIAM DALL'ACQUA

发明人： GENEVIEVE LOSONSKY ,  EDWARD M. CONNOR ,  JAMES F. YOUNG ,  HERREN WU ,  WILLIAM DALL'ACQUA

IPC分类号： A61K39/42 ,  A61P31/14

CPC分类号： C07K16/1027 ,  A61K2039/505 ,  A61K2039/543 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/72 ,  C07K2317/92 ,  C07K2317/94

摘要： The present invention provides methods for preventing, managing, treating and/or ameliorating a Respiratory Syncytial Virus (RSV) infection (e.g., acute RSV disease, or a RSV upper respiratory tract infection (URI) and/or lower respiratory tract infection (LRI)), otitis media (preferably, stemming from, caused by or associated with a RSV infection, such as a RSV URI and/or LRI), and/or a symptom or respiratory condition relating thereto (e.g., asthma, wheezing, and/or reactive airway disease (RAD)) in a subject, comprising administering to said human an effective amount of one or more antibodies that immunospecifically bind to one or more RSV antigens with a high affinity and/or high avidity. In some embodiments, one or more antibodies comprise a modified IgG constant domain, or FcRn-binding fragment thereof resulting in longer in vivo serum half-life. In particular embodiments the methods of the invention comprising administering to subject an effective amount of one or more modified antibodies that immunospecifically bind to one or more RSV antigens with an association rate (kon) of at least 2×105 M−1 s−1 and a dissociation rate (koff) of less than 5×10−4 s−1.

摘要翻译： 本发明提供了用于预防，治疗和/或改善呼吸道合胞病毒（RSV）感染（例如急性RSV疾病或RSV上呼吸道感染（URI））和/或下呼吸道感染（LRI）的方法， ），中耳炎（优选来源于，由RSV感染引起或与RSV感染相关联，例如RSV URI和/或LRI），和/或与其相关的症状或呼吸病症（例如，哮喘，喘息和/或 反应性气道疾病（RAD）），包括向所述人施用有效量的一种或多种以高亲和力和/或高亲合力免疫特异性结合一种或多种RSV抗原的抗体。 在一些实施方案中，一种或多种抗体包含修饰的IgG恒定结构域或其FcRn结合片段，导致更长的体内血清半衰期。 在具体实施方案中，本发明的方法包括施用有效量的一种或多种经免疫特异性结合一种或多种具有至少2×105M-1s-1的缔合率（kon）的RSV抗原的修饰的抗体，以及 解离速率（koff）小于5×10-4 s-1。

公开(公告)号：US20120070447A1

公开(公告)日：2012-03-22

申请号：US12906948

申请日：2010-10-18

申请人： JAMES F. YOUNG ,  SCOTT KOENIG ,  LESLIE S. JOHNSON ,  WILLIAM D. HUSE ,  JEFFREY D. WATKINS ,  HERREN WU

发明人： JAMES F. YOUNG ,  SCOTT KOENIG ,  LESLIE S. JOHNSON ,  WILLIAM D. HUSE ,  JEFFREY D. WATKINS ,  HERREN WU

IPC分类号： A61K39/42 ,  C12N15/13 ,  C07K16/46 ,  A61P31/14 ,  C12N1/21 ,  C12N5/10 ,  C12P21/00 ,  C12Q1/70 ,  C12N1/19 ,  C07K16/10 ,  C12N15/63

CPC分类号： C07K16/1027 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565

摘要： The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention also encompasses methods for treating or ameliorating symptoms associated with a RSV infection in a human, comprising administering to said human a therapeutically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention further encompasses compositions comprising antibodies or fragments thereof that immunospecifically bind to a RSV antigen, and methods using said compositions for detection or diagnosis a RSV infection

摘要翻译： 本发明包括免疫特异性结合一种或多种RSV抗原的新型抗体及其片段，以及包含所述抗体和抗体片段的组合物。 本发明包括预防人类呼吸道合胞病毒（RSV）感染的方法，包括向所述人施用预防有效量的一种或多种免疫特异性结合一种或多种RSV抗原的抗体或其片段，其中一定的血清滴度为 所述抗体或抗体片段在所述人受试者中实现。 本发明还包括用于治疗或改善与人类RSV感染有关的症状的方法，包括向所述人施用治疗有效量的一种或多种免疫特异性结合一种或多种RSV抗原的抗体或其片段，其中一定 所述抗体或抗体片段的血清滴度在所述人受试者中实现。 本发明还包括包含免疫特异性结合RSV抗原的抗体或其片段的组合物，以及使用所述组合物检测或诊断RSV感染的方法

公开(公告)号：US20100239574A1

公开(公告)日：2010-09-23

申请号：US12707527

申请日：2010-02-17

申请人： JAMES F. YOUNG ,  LESLIE S. JOHNSON ,  WILLIAM D. HUSE ,  HERREN WU ,  JEFFRY D. WATKINS

发明人： JAMES F. YOUNG ,  LESLIE S. JOHNSON ,  WILLIAM D. HUSE ,  HERREN WU ,  JEFFRY D. WATKINS

IPC分类号： A61K39/42 ,  A61P31/14 ,  A61P11/00

CPC分类号： C07K16/1027 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/567

摘要： High potency antibodies, including immunologically active fragments thereof, having high kinetic association rate constants and optional high affinities are disclosed, along with methods for producing such antibodies. The high potency antibodies disclosed herein are of either the neutralizing or non-neutralizing type and have specificity for antigens displayed by microorganisms, especially viruses, as well as antigenic sites present on cancer cells and on various types of toxins, and the products of toxins. Processes for producing high potency neutralizing antibodies and increasing the potency of already existing neutralizing antibodies are also described. Methods of using said antibodies in the prevention and/or treatment of diseases, especially diseases induced or caused by viruses, are disclosed.

摘要翻译： 公开了具有高动力学关联速率常数和任选的高亲和力的高效力抗体，包括其免疫活性片段，以及产生此类抗体的方法。 本文公开的高效抗体是中和或非中和型，并且对由微生物，特别是病毒以及存在于癌细胞和各种类型毒素上的抗原位点以及毒素产物显示的抗原具有特异性。 还描述了用于产生高效中和抗体并增加已经存在的中和抗体的效力的方法。 公开了在预防和/或治疗疾病，特别是由病毒引起或引起的疾病中使用所述抗体的方法。