专利检索 ap:("GENFLEET THERAPEUTICS (SHANGHAI) INC." OR "ZHEJIANG GENFLEET THERAPEUTICS CO., LTD.") AND inv:"Ling PENG" 第 1 页

1.

发明公开
FUSED TRICYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF 审中-公开

公开(公告)号：US20230203060A1

公开(公告)日：2023-06-29

申请号：US17927961

申请日：2021-05-27

申请人： GENFLEET THERAPEUTICS (SHANGHAI) INC. , ZHEJIANG GENFLEET THERAPEUTICS CO., LTD.

发明人： Fusheng ZHOU , Tao JIANG , Yingtao LIU , Jichen ZHAO , Wan HE , Zhubo LIU , Ling PENG , Lijian CAI , Leitao ZHANG , Chonglan LIN , Huabin YANG , Tao ZHANG , Jiong LAN

IPC分类号： C07D498/14 , C07D519/00 , C07D498/04 , C07D487/14 , A61P35/00

CPC分类号： C07D498/14 , C07D519/00 , C07D498/04 , C07D487/14 , A61P35/00 , C07B2200/05

摘要： Provided are a fused tricyclic compound having the structure shown in formula (I), a pharmaceutical composition thereof, and a use thereof. The fused tricyclic compound serves as a selective inhibitor of KRAS mutation, and has high activity, good selectivity. and reduced toxic side effects.

2.

发明申请
OXAAZAQUINAZOLINE-7(8H)-KETONE COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF 有权

公开(公告)号：US20220251109A1

公开(公告)日：2022-08-11

申请号：US17607311

申请日：2020-04-28

申请人： GENFLEET THERAPEUTICS (SHANGHAI) INC. , ZHEJIANG GENFLEET THERAPEUTICS CO., LTD.

发明人： Fusheng ZHOU , Lijian CAI , Tao JIANG , Jichen ZHAO , Yingtao LIU , Jinzhu ZHAO , Leitao ZHANG , Zhubo LIU , Ling PENG , Wan HE , Huabin YANG , Tao ZHANG , Qian DING , Biao ZHENG , Qiang LV , Jiong LAN

IPC分类号： C07D498/22 , C07D498/14 , C07D498/16

摘要： An oxaazaquinazolin-7(8H)-ketone compound with a selective inhibition effect on KRAS gene mutation and pharmaceutically acceptable salts thereof, stereoisomers, solvent compounds or prodrugs (as shown in formula I or formula II, see the details of the definition to each group in the formulas in the specification), as well as the pharmaceutical composition containing the compound, and the application thereof in preparation of cancer medicine.

3.

发明公开
FUSED RING SUBSTITUTED SIX-MEMBERED HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF 审中-公开

公开(公告)号：US20240182465A1

公开(公告)日：2024-06-06

申请号：US18280208

申请日：2022-03-03

申请人： GENFLEET THERAPEUTICS (SHANGHAI) INC. , ZHEJIANG GENFLEET THERAPEUTICS CO., LTD.

发明人： Fusheng ZHOU , Jichen ZHAO , Wan HE , Chonglan LIN , Ling PENG , Huabin YANG , Zhen LI , Xiaoling LAN , Mei GE , Qian DING , Xiang YU , Jiong LAN , Qiang LU

IPC分类号： C07D471/04 , C07D401/14 , C07D405/14 , C07D417/14

CPC分类号： C07D471/04 , C07D401/14 , C07D405/14 , C07D417/14

摘要： A compound having HPK1 inhibitory activity as shown in formula (IA) or (IC), and a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof, and a pharmaceutical composition containing the compound, and use of same in preparation of a drug for preventing and/or treating diseases or conditions associated with HPK1 activity.