-
公开(公告)号：US20240150484A1
公开(公告)日：2024-05-09
申请号：US18281372
申请日：2022-03-11
Applicant: GENMAB A/S
Inventor： Bart-Jan DE KREUK , Richard HIBBERT , Janine SCHUURMAN , Aran F. LABRIJN
CPC classification number: C07K16/2887 , C07K1/1075 , C07K16/18 , C07K16/2809 , C07K16/2833 , C07K16/32 , C07K2317/31 , C07K2317/54 , C07K2317/92 , C07K2317/94
Abstract: Described herein are proteins comprising an Fc region or the like, such as monoclonal, bispecific and multispecific antibodies, wherein the Fc region has been modified to eliminate or strongly reduce Fc-mediated effector functions, while at the same time allow for good developability, for therapeutic purposes and where such effector functions are undesired.
-
公开(公告)号：US20180201693A1
公开(公告)日：2018-07-19
申请号：US15742803
申请日：2016-07-01
Applicant: GENMAB A/S
Inventor： Richard G. HIBBERT , Aran F. LABRIJN , Arnout F. GERRITSEN , Janine SCHUURMAN , Paul PARREN
IPC: C07K16/46
CPC classification number: C07K16/468 , C07K16/2863 , C07K16/2887 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/515 , C07K2317/526 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2317/94
Abstract: Bispecific and multispecific antibodies having differentially modified light chains, that allows for isolation of the bispecific or multispecific antibodies based on a differential affinity towards an affinity reagent.
-
公开(公告)号：US20170327597A1
公开(公告)日：2017-11-16
申请号：US15536143
申请日：2015-12-18
Applicant: GENMAB A/S
Inventor： Aran F. LABRIJN , Joyce I. MEESTERS , Janine SCHUURMAN , Paul PARREN , Anthony ARMSTRONG , Matthew BUNCE , Mark CHIU , Thomas NESSPOR , Adam ZWOLAK
CPC classification number: C07K16/462 , A61K49/0008 , C07K16/00 , C07K16/2809 , C07K16/32 , C07K16/40 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/526 , C07K2317/64 , C07K2317/73
Abstract: Novel rodent bispecific heterodimeric proteins, such as rodent bispecific antibodies, in vitro method for producing such, and uses thereof.
-
-
Search Results
3
records
(took 0.01 seconds)
