公开(公告)号：US20190030180A1

公开(公告)日：2019-01-31

申请号：US16069391

申请日：2017-01-13

Applicant: GENMAB A/S

Inventor： Lene Schantz HARLOW ,  Timothy Warren PAUL ,  Brendan M. MAYHUGH ,  Kelly Ann ROBY ,  Gregory Allan SACHA ,  Xiaona JING ,  Andrew HAGARMAN ,  Cale HALBLEIB

IPC: A61K47/68 ,  A61K9/19 ,  C07K16/28 ,  A61K38/07 ,  A61K47/18 ,  A61K47/26

Abstract: Disclosed herein are surfactant free antibody and antibody-drug-conjugate (ADC) formulations for anti-AXL antibodies and ADCs, including aqueous formulations, lyophilized formulations, and reconstituted formulations, as well as related processes and uses. The formulations are particularly suitable for an anti-AXL ADC based on an auristatin or DM1 derivative or other similarly hydrophobic drugs. Some formulations comprise histidine and mannitol.