公开(公告)号：US20220133721A1

公开(公告)日：2022-05-05

申请号：US17346851

申请日：2021-06-14

Applicant: GENMAB A/S

Inventor： Daniel Simon PEEPER ,  Judith Nadja MUELLER

IPC: A61K31/506 ,  A61K45/06 ,  A61K31/437 ,  A61K31/519 ,  A61K31/502 ,  C12Q1/6886 ,  G01N33/574

Abstract: The current disclosure relates to pharmaceutical combinations and compositions useful in the treatment of certain types of cancer. The disclosure also relates to methods for treatment of these types of cancer. In particular, the disclosure relates to the combined use of of an inhibitor of a protein of the MAPK/ERK pathway and an inhibitor of specific kinases in the treatment of a cancer, in particular melanoma, in a patient. In an important embodiment, the cancer is characterized by the absence or reduced expression of MITF.