公开(公告)号：US20240091373A1

公开(公告)日：2024-03-21

申请号：US18065196

申请日：2022-12-13

Applicant: Genmab A/S

Inventor： Jesper VALBJØRN ,  Xiaona JING ,  Kelly Ann ROBY ,  Timothy Warren PAUL ,  Gregory Allan SACHA ,  Nathan Alan PEASE ,  Bodil WILLUMSEN

IPC: A61K47/68 ,  A61K9/19 ,  A61K39/395 ,  A61K47/22 ,  C07K16/36

CPC classification number: A61K47/6843 ,  A61K9/19 ,  A61K39/39591 ,  A61K47/22 ,  A61K47/6803 ,  A61K47/6889 ,  C07K16/36 ,  A61K47/183 ,  C07K2317/77

Abstract: Disclosed herein are surfactant free lyophilized formulations of antibody-drug conjugates (ADCs), such as anti-tissue factor ADCs, and reconstituted formulations, processes and uses thereof. The formulations are particularly suitable for an anti-TF ADC based on an auristatin derivative or other similarly hydrophobic drug. Typically, the excipients of the formulations comprise or consist of histidine, sucrose, trehalose, mannitol and glycine.

公开(公告)号：US20200246477A1

公开(公告)日：2020-08-06

申请号：US16742158

申请日：2020-01-14

Applicant: GENMAB A/S

Inventor： Jesper VALBJØRN ,  Xiaona JING ,  Kelly Ann ROBY ,  Timothy Warren PAUL ,  Gregory Allan SACHA ,  Nathan Alan PEASE ,  Bodil WILLUMSEN

IPC: A61K47/68 ,  A61K9/19 ,  A61K39/395 ,  A61K47/22 ,  C07K16/36 ,  A61K47/26 ,  A61K47/18

Abstract: Disclosed herein are surfactant free lyophilized formulations of antibody-drug conjugates (ADCs), such as anti-tissue factor ADCs, and reconstituted formulations, processes and uses thereof. The formulations are particularly suitable for an anti-TF ADC based on an auristatin derivative or other similarly hydrophobic drug. Typically, the excipients of the formulations comprise or consist of histidine, sucrose, trehalose, mannitol and glycine.

公开(公告)号：US20160279258A1

公开(公告)日：2016-09-29

申请号：US15038235

申请日：2014-11-21

Applicant: GENMAB A/S

Inventor： Jesper VALBJØRN ,  Xiaona JING ,  Kelly Ann ROBY ,  Timothy Warren PAUL ,  Gregory Allan SACHA ,  Nathan Alan PEASE ,  Bodil WILLUMSEN

IPC: A61K47/48 ,  A61K47/26 ,  A61K47/22 ,  A61K9/19 ,  C07K16/36

CPC classification number: A61K47/48538 ,  A61K9/19 ,  A61K39/39591 ,  A61K47/183 ,  A61K47/22 ,  A61K47/26 ,  A61K47/6803 ,  A61K47/6843 ,  A61K47/6889 ,  C07K16/36 ,  C07K2317/21 ,  C07K2317/77 ,  C07K2317/94

Abstract: Disclosed herein are surfactant free lyophilized formulations of antibody-drug conjugates (ADCs), such as anti-tissue factor ADCs, and reconstituted formulations, processes and uses thereof. The formulations are particularly suitable for an anti-TF ADC based on an auristatin derivative or other similarly hydrophobic drug. Typically, the excipients of the formulations comprise or consist of histidine, sucrose, trehalose, mannitol and glycine.

Abstract translation: 本文公开了抗体 - 药物偶联物（ADC）的无表面活性剂的冻干制剂，例如抗组织因子ADC，以及重构的制剂，方法和用途。 该制剂特别适用于基于阿司匹林衍生物或其它类似疏水性药物的抗TF ADC。 通常，制剂的赋形剂包含组氨酸，蔗糖，海藻糖，甘露糖醇和甘氨酸。