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公开(公告)号：US20200181277A1
公开(公告)日：2020-06-11
申请号：US16482747
申请日：2018-02-12
Applicant: GENMAB B.V.
Inventor： Frank BEURSKENS , Marije OVERDIJK , Annieck M. DIKS , Rob DE JONG , Kristin STRUMANE , Janine SCHUURMAN , Paul PARREN
Abstract: As described herein are polypeptides and antibodies having an Fc region and an antigen binding region where the Fc region has an Fc-Fc-enhancing mutation and a C1q binding-enhancing mutation providing for polypeptides or antibodies with increased CDC activity and/or agonistic activity.
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