公开(公告)号：US20210238296A1

公开(公告)日：2021-08-05

申请号：US17051205

申请日：2019-05-03

Applicant: GENMAB B.V.

Inventor： Rob DE JONG ,  Frank BEURSKENS ,  Simone OOSTINDIE ,  Aran Frank LABRIJN ,  Kristin STRUMANE ,  Janine SCHUURMAN ,  Bart-Jan DE KREUK

IPC: C07K16/28 ,  A61K45/06

Abstract: Provided herein are combinations of first and second antibodies having modified Fc effector functions resulting from amino acid substitutions in the Fc region, the amino acid substitutions allow for co-dependent activation of effector functions such as CDC and/or ADCC. Also provided are combinations of first and second antibodies having agonistic activity or enhanced agonistic activity resulting from amino acid substitutions in the Fc region where the agonistic activity is co-dependent of both a first and second antibodies.