公开(公告)号：US20170260281A1

公开(公告)日：2017-09-14

申请号：US15436583

申请日：2017-02-17

Applicant: GENMAB B.V.

Inventor： Claudine Brigitte Fernande Vermot-Desroches ,  Olivier Frédéric Subiger ,  Laurence Françoise Jeanne-Marie

IPC: C07K16/28

CPC classification number: C07K16/2878 ,  A61K2039/507 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/75

Abstract: Anti-DR5 family member antibodies and bispecific antibodies comprising one or more anti-DR5 family member antibodies are disclosed. These antibodies can be used to trigger cell death on DR5 positive cells.