公开(公告)号：US20220315661A1

公开(公告)日：2022-10-06

申请号：US17609359

申请日：2020-05-11

Applicant: GENMAB B.V.

Inventor： Ulf FORSSMANN ,  Manish GUPTA ,  Jens Thing MORTENSEN ,  Merete ELLEKILDE-PEDERSEN ,  Marije Berber OVERDIJK ,  Tahamtan AHMADI

IPC: C07K16/28 ,  A61P35/00 ,  A61K39/395 ,  A61K31/573 ,  A61P35/02

Abstract: The present invention relates to a combination of two antibody molecules that bind to human DR5 antigen and their use in treating cancer. In particular, the present invention relates to dosage regimens for such anti-DR5 antibodies comprising administering to subject weekly dosages followed by biweekly dosages, or one or two priming dosage(s) followed by biweekly dosages.