公开(公告)号：US20220332801A1

公开(公告)日：2022-10-20

申请号：US17534712

申请日：2021-11-24

申请人： GENMAB B.V.

发明人： Annemarie KUIPERS ,  Kok VAN KESSEL ,  Frank BEURSKENS ,  Rob DE JONG ,  Kristin STRUMANE ,  Janine SCHUURMAN ,  Paul PARREN ,  Jos VAN STRIJP ,  Suzan ROOIJAKKERS

IPC分类号： C07K16/12 ,  A61P31/04

摘要： The present invention relates to antibody molecules that bind to Wall Teichoic Acid (WTA) or Capsular Polysaccharides (CP) such as Capsular Polysaccharides type 5 (CP5). The invention relates in particular to antibody molecules of the IgG isotype having a mutation in the Fc domain that enhances clustering of IgG molecules after target binding. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of infectious diseases using these compositions