公开(公告)号：US20140296085A1

公开(公告)日：2014-10-02

申请号：US14355642

申请日：2012-11-02

Applicant: GENOMIC HEALTH, INC.

Inventor： Joffre B. Baker ,  Dominick S. Sinicropi ,  Robert J. Pelham ,  Michael R. Crager ,  Francois Collin ,  James C. Stephans ,  Mei-Lan Liu ,  John D. Morlan ,  Kunbin Qu

IPC: G06F19/18 ,  C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q1/686 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/57415 ,  G01N2800/54 ,  G01N2800/56 ,  G01N2800/60 ,  G16B20/00

Abstract: The present invention relates to biomarkers associated with breast cancer prognosis. These biomarkers include coding transcripts and their expression products, as well as non-coding transcripts, and are useful for predicting the likelihood of breast cancer recurrence in a breast cancer patient, The present invention also relates to a novel method of identifying intergenic sequences that correlate with a clinical outcome.

Abstract translation: 本发明涉及与乳腺癌预后相关的生物标志物。 这些生物标志物包括编码转录物及其表达产物，以及非编码转录物，并且可用于预测乳腺癌患者乳腺癌复发的可能性。本发明还涉及一种鉴定与之相关的基因间序列的新方法 具有临床结果。