公开(公告)号：US20110214189A1

公开(公告)日：2011-09-01

申请号：US12916227

申请日：2010-10-29

申请人： GEORGE A. GAITANARIS ,  JOHN E. BERGMANN ,  ALEXANDER GRAGEROV ,  JOHN HOHMANN ,  FUSHENG LI ,  LINDA MADISEN ,  KELLIE L. MCILWAIN ,  MARIA N. PAVLOVA ,  DEMETRI VASSILATIS ,  HONGKUI ZENG

发明人： GEORGE A. GAITANARIS ,  JOHN E. BERGMANN ,  ALEXANDER GRAGEROV ,  JOHN HOHMANN ,  FUSHENG LI ,  LINDA MADISEN ,  KELLIE L. MCILWAIN ,  MARIA N. PAVLOVA ,  DEMETRI VASSILATIS ,  HONGKUI ZENG

IPC分类号： A61K49/00 ,  C12N5/10 ,  C12Q1/02 ,  A01K67/027

CPC分类号： A01K67/0278 ,  A01K2217/00 ,  A01K2217/052 ,  A01K2227/105 ,  A01K2267/03 ,  A61K38/00 ,  A61K49/0008 ,  C07K14/723 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/5023 ,  G01N2333/726 ,  G01N2800/04 ,  G01N2800/28 ,  G01N2800/50

摘要： The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and disorders. The invention also provides methods for identifying compounds (e.g., agonists or antagonists) using the GPCR polypeptides and polynucleotides of the invention, and for treating conditions associated with GPCR dysfunction with the GPCR polypeptides, polynucleotides, or identified compounds. The invention also provides diagnostic assays for detecting diseases or disorders associated with inappropriate GPCR activity or levels.