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公开(公告)号:US20220305031A1
公开(公告)日:2022-09-29
申请号:US17618302
申请日:2020-06-11
发明人: Robert I. GLAZER , Moshe LEVI , Hongyan YUAN , Suman RANJIT
IPC分类号: A61K31/575 , A61K31/337 , A61K31/704 , A61K31/513 , A61K31/675 , A61K33/243 , A61K31/282 , A61K31/395 , A61K31/7068 , A61K31/475 , A61P35/00
摘要: Aspects of the technology described herein relate to a method of treating a malignancy in a subject. This method involves selecting a subject having a malignancy and administering dimethyl-3-beta-hydroxy-cholenamide (DMHCA) or derivative thereof to the subject in an amount effective to treat the malignancy. Methods of reducing malignancy-associated fibrosis in a subject and pharmaceutical combinations comprising (i) DMHCA or derivative thereof and (ii) one or more immune checkpoint inhibitors are also disclosed.