专利检索 ap:("GI INNOVATION, INC.") AND inv:"Bo-Gie YANG" 第 1 页

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发明申请
POLYPEPTIDE DIMER WITH HIGH SIALIC ACID CONTENT, COMPRISING EXTRACELLULAR DOMAIN OF ALPHA SUBUNIT OF IGE FC RECEPTOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 有权

公开(公告)号：US20220257693A1

公开(公告)日：2022-08-18

申请号：US17625668

申请日：2020-07-07

申请人： GI INNOVATION, INC.

发明人： Myoung Ho JANG , Bo-Gie YANG , Kyungwha LEE

IPC分类号： A61K38/00 , A61K9/00 , A61K9/70 , A23L33/18 , A61P37/08 , C07K14/735

摘要： A modified IgE Fc receptor having a high content of sialic acid and a pharmaceutical composition contains the modified IgE Fc receptor are disclosed. The polypeptide dimer having a high content of sialic acid not only has excellent safety and persistence in a body as compared with conventionally used anti-IgE antibodies, but also shows strong binding to IgE. Thus, the polypeptide has the advantage of an extended administration cycle. The polypeptide dimer is also an IgE single target substance, and unlike conventional anti-IgE antibodies to which the Fc of IgG1 is applied, does not bind to an Fc gamma receptor. The polypeptide dimer can be usefully used for the prevention or treatment of allergic diseases.