公开(公告)号：US10266539B2

公开(公告)日：2019-04-23

申请号：US15788583

申请日：2017-10-19

Applicant: Gilead Connecticut, Inc.

Inventor： Tim G. Elford ,  Peter Chee-Chu Fung ,  Michael Laird Hurrey ,  Dimitrios Stefanidis ,  Dragos Vizitiu

IPC: C07D487/04 ,  C07C309/04

Abstract: Polymorphs of a bis-mesylate salt of a compound of Formula I: or a hydrate thereof, are provided. The bis-mesylate salt may also be depicted as a compound of Formula IA: Provided herein are also compositions thereof, methods for their preparation and methods for such polymorphs.

公开(公告)号：US20170217967A1

公开(公告)日：2017-08-03

申请号：US15484844

申请日：2017-04-11

Applicant: Gilead Connecticut, Inc.

Inventor： Tim G. Elford ,  Peter Chee-Chu Fung ,  Michael Laird Hurrey ,  Dimitrios Stefanidis ,  Dragos Vizitiu

IPC: C07D487/04

CPC classification number: C07D487/04 ,  C07C309/04

Abstract: Polymorphs of a bis-mesylate salt of a compound of Formula I: or a hydrate thereof, are provided. The bis-mesylate salt may also be depicted as a compound of Formula IA: Provided herein are also compositions thereof, methods for their preparation and methods for such polymorphs.

公开(公告)号：US20180099971A1

公开(公告)日：2018-04-12

申请号：US15788583

申请日：2017-10-19

Applicant: Gilead Connecticut, Inc.

Inventor： Tim G. Elford ,  Peter Chee-Chu Fung ,  Michael Laird Hurrey ,  Dimitrios Stefanidis ,  Dragos Vizitiu

IPC: C07D487/04 ,  C07C309/04

CPC classification number: C07D487/04 ,  C07C309/04

Abstract: Polymorphs of a bis-mesylate salt of a compound of Formula I: or a hydrate thereof, are provided. The bis-mesylate salt may also be depicted as a compound of Formula IA: Provided herein are also compositions thereof, methods for their preparation and methods for such polymorphs.

公开(公告)号：US09657023B2

公开(公告)日：2017-05-23

申请号：US14446011

申请日：2014-07-29

Applicant: Gilead Connecticut, Inc.

Inventor： Tim G. Elford ,  Peter Chee-Chu Fung ,  Michael Laird Hurrey ,  Dimitrios Stefanidis ,  Dragos Vizitiu

IPC: C07D487/04 ,  C07C309/04

CPC classification number: C07D487/04 ,  C07C309/04

Abstract: Polymorphs of a bis-mesylate salt of a compound of Formula I: or a hydrate thereof, are provided. The bis-mesylate salt may also be depicted as a compound of Formula IA: Provided herein are also compositions thereof, methods for their preparation and methods for such polymorphs.

公开(公告)号：US20160168155A1

公开(公告)日：2016-06-16

申请号：US14907767

申请日：2014-07-29

Applicant: GILEAD CONNECTICUT, INC.

Inventor： Peter Chee-Chu Fung ,  Dimitrios Stefanidis ,  Dragos Vizitiu ,  Tim G. Elford ,  Michael Laird Hurrey

IPC: C07D487/04

CPC classification number: C07D487/04 ,  C07C309/04

Abstract: Polymorphs of a bis-mesylate salt of a compound of Formula (I): or a hydrate thereof, are provided. The bis-mesylate salt may also be depicted as a compound of Formula (IA): Provided herein are also compositions thereof, methods for their preparation and methods for such polymorphs.

Abstract translation: 提供式（I）化合物的双甲磺酸盐或其水合物的多晶型物。 双甲磺酸盐也可以描述为式（IA）的化合物：本文还提供其组合物，其制备方法和这些多晶型物的方法。