公开(公告)号：US20190298854A1

公开(公告)日：2019-10-03

申请号：US16082674

申请日：2017-03-06

申请人： GLAXOSMITHKLINE BIOLOGICALS, SA ,  Liquidia Technologies, Inc.

发明人： Abdelatif A ELOUAHABI ,  Patrick POHLHAUS ,  Laurent Bernard Jean STRODIOT ,  Ashley GALLOWAY ,  Jin Christiane Lee ,  Michele R. STONE

IPC分类号： A61K47/69 ,  A61K9/16 ,  A61K47/64 ,  A61K47/61 ,  A61K39/08 ,  A61K39/102

摘要： The present invention concerns drug delivery particles which can prevent interaction between a biologically-active cargo comprised within the particles and components of an aqueous environment in which said particles are present. The particles are sensitive to pH such that above a threshold pH level the biologically-active cargo becomes accessible to the surrounding environment. Such particles are accordingly useful for stably storing a biologically-active cargo in an aqueous composition containing components which would otherwise interact deleteriously with the cargo, and releasing the cargo to mediate a biological effect in the body of an animal, such as a human, to which the composition is administered. Also provided are compositions comprising such particles, as well as methods for making and using such particles and compositions.