公开(公告)号：US20190142949A1

公开(公告)日：2019-05-16

申请号：US16244186

申请日：2019-01-10

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： John Alexander BROWN ,  Katherine Louise Jones ,  Rabinder Kumar Prinjha ,  Jason Witherington

IPC: A61K47/54 ,  A61K31/4709 ,  A61K31/4439 ,  C07D405/14 ,  C07D401/12 ,  C07D401/04

Abstract: The present invention relates to covalent conjugates of BET inhibitors and alpha amino acid esters, processes for their preparation, compositions containing them, and to their use in the treatment of various disorders in particular inflammatory and autoimmune diseases, such as rheumatoid arthritis; and cancers.