公开(公告)号：US12234293B2

公开(公告)日：2025-02-25

申请号：US17846950

申请日：2022-06-22

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Sanjay Khandekar ,  Patrick Mayes ,  Joanna Opalinska

IPC: A61K39/395 ,  A61K31/573 ,  A61K31/69 ,  A61K47/68 ,  A61P35/00 ,  C07K16/28 ,  C07K16/30 ,  C07K19/00 ,  A61K39/00 ,  C07K14/71

Abstract: Disclosed herein is a method of treating cancer, such as multiple myeloma, involving the combination of an anti-BCMA antigen binding protein (e.g., an anti-BCMA antibody) and a proteasome inhibitor (e.g. bortezomib). The combinations can also include an anti-inflammatory compound (e.g. dexamethasone).

公开(公告)号：US12227585B2

公开(公告)日：2025-02-18

申请号：US18453404

申请日：2023-08-22

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Sanjay Khandekar ,  Patrick Mayes ,  Joanna Opalinska

IPC: C07K16/28 ,  A61K31/454 ,  A61K31/573 ,  A61K39/395 ,  A61K47/68 ,  A61P35/00

Abstract: Disclosed herein is a method of treating cancer, such as multiple myeloma, involving the combination of an anti-BCMA antigen binding protein (e.g., an anti-BCMA antibody) and an immunomodulatory drug (e.g. pomalidomide or lenalidomide). The combinations can also include an anti-inflammatory compound (e.g. dexamethasone).