公开(公告)号：US20210163472A1

公开(公告)日：2021-06-03

申请号：US16770673

申请日：2018-12-12

申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

发明人： Gianpaolo BRAVI ,  Heather HOBBS ,  Graham George Adam INGLIS ,  Simon NICOLLE ,  Simon PEACE

IPC分类号： C07D471/04 ,  A61P11/00 ,  C07D519/00

摘要： The invention relates to compounds of formula (I): wherein R1, R2, R3, R4, L and A are as defined in the description and claims, or pharmaceutically acceptable salts thereof having mTOR kinase inhibitor activity. The invention also relates to pharmaceutical compositions including a compound of formula (I) or a pharmaceutically acceptable salt thereof, and to the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in therapy, including in the treatment of a disease or condition for which an mTOR kinase inhibitor activity is indicated, and in particular the treatment of idiopathic pulmonary fibrosis.