公开(公告)号：US20180044348A1

公开(公告)日：2018-02-15

申请号：US15791563

申请日：2017-10-24

申请人： Grünenthal Gmbh

发明人： Klaus WENING ,  Lutz BARNSCHEID ,  Anja GEISSLER ,  Jana DENKER ,  Dagmar LISCHKE

IPC分类号： C07D489/04

CPC分类号： C07D489/04 ,  C07B2200/13

摘要： Crystalline salts of 7,8-Didehydro-4,5 alpha-epoxy-17-methylmorphinan-3,6 alpha-diol sulfate(2:1), i.e. of morphine sulphate, are disclosed and four polymorphic forms of these salts are reported. The invention further relates to a pharmaceutical composition comprising an amount of such a salt and such a salt as a medicament and for the treatment and/or prevention of pain.

公开(公告)号：US20180177732A1

公开(公告)日：2018-06-28

申请号：US15901063

申请日：2018-02-21

申请人： GRÜNENTHAL GMBH

发明人： Lutz BARNSCHEID ,  Eric GALIA ,  Sebastian SCHWIER ,  Ulrike BERTRAM ,  Anja GEISSLER ,  Kornelia GRIESSMANN ,  Johannes BARTHOLOMÄUS

IPC分类号： A61K9/20 ,  A61K31/485 ,  A61K9/28

CPC分类号： A61K9/2013 ,  A61K9/20 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2095 ,  A61K9/284 ,  A61K31/485

摘要： A thermoformed pharmaceutical dosage form having a breaking strength of at least 300 N, said dosage form comprising a pharmacologically active ingredient (A), a free physiologically acceptable acid (B) in an amount of from 0.001 wt.-% to 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form, and a polyalkylene oxide (C) having a weight average molecular weight Mw of at least 200,000 g/mol.

公开(公告)号：US20180044347A1

公开(公告)日：2018-02-15

申请号：US15791508

申请日：2017-10-24

申请人： GRÜNENTHAL GMBH

发明人： Klaus WENING ,  Lutz BARNSCHEID ,  Anja GEISSLER ,  Jana DENKER ,  Dagmar LISCHKE

IPC分类号： C07D489/04

CPC分类号： C07D489/04 ,  A61P25/04 ,  A61P29/00 ,  C07B2200/13 ,  C07D489/02

摘要： Crystalline salts of 4,5 α-epoxy-3-methoxy-17-methylmorphinan-6-one tartrate (1:1) (hydrocodone bitartrate) are disclosed and three polymorphic forms of these salts are reported. The invention further relates to a pharmaceutical composition comprising such a salt and such a salt as a medicament and for the treatment and/or prevention of pain.

公开(公告)号：US20150366809A1

公开(公告)日：2015-12-24

申请号：US14841829

申请日：2015-09-01

申请人： GRÜNENTHAL GMBH

发明人： Lutz BARNSCHEID ,  Eric GALIA ,  Sebastian SCHWIER ,  Ulrike BERTRAM ,  Anja GEISSLER ,  Kornelia GRIESSMANN ,  Johannes BARTHOLOMÄUS

IPC分类号： A61K9/20 ,  A61K31/485

CPC分类号： A61K9/2013 ,  A61K9/20 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2095 ,  A61K9/284 ,  A61K31/485

摘要： A thermoformed pharmaceutical dosage form having a breaking strength of at least 300 N, said dosage form comprising a pharmacologically active ingredient (A), a free physiologically acceptable acid (B) in an amount of from 0.001 wt.-% to 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form, and a polyalkylene oxide (C) having a weight average molecular weight Mw of at least 200,000 g/mol.

摘要翻译： 一种具有至少300N断裂强度的热成型药物剂型，所述剂型包含药理学活性成分（A），游离生理上可接受的酸（B），其量为0.001重量％至5.0重量％ ％，基于药物剂型的总重量，以及重均分子量Mw至少为200,000g / mol的聚环氧烷（C）。