公开(公告)号：US11547678B2

公开(公告)日：2023-01-10

申请号：US16662392

申请日：2019-10-24

申请人： GRÜNENTHAL GMBH

发明人： Ulrich Reinhold ,  Marc Schiller ,  Eva Wulsten ,  Sabine Karine Katrien Inghelbrecht ,  Roger Carolus Augusta Embrechts ,  Ulrich Feil

IPC分类号： A61K9/08 ,  A61K31/137 ,  A61K47/12 ,  A61K9/00 ,  A61K47/02

摘要： An aqueous pharmaceutical composition containing tapentadol or a physiologically acceptable salt thereof and being adapted for oral administration. The composition has excellent storage stability without relying on the presence of high amounts of preservatives.