公开(公告)号：US20220135679A1

公开(公告)日：2022-05-05

申请号：US17431218

申请日：2020-04-06

Applicant: GREEN CROSS CORPORATION

Inventor： Jae Chan PARK ,  Eun Jung SONG ,  So Jung LIM ,  Jae-Chul LEE ,  Hae Naem KWON ,  Su A LEE ,  Ok Jae LIM ,  Mun Kyung KIM ,  Hyun Jung CHO ,  Gil-Jung KIM ,  Jee Won LEE ,  Sung Keun KIM ,  Jong Wha WON ,  Shin A JANG

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/30

Abstract: A bispecific anti-GPNMB/anti-CD3 antibody specifically binds to CD3 (cluster of differentiation 3) and GPNMB (glycoprotein non-metastatic melanoma protein B) and uses thereof are disclosed. The bispecific antibody shows high affinity and specificity to CD3 and GPNMB and thus can induce death of cancer cells expressing GPNMB and inhibit proliferation thereof. Therefore, the bispecific antibody can be used as an effective therapeutic agent for cancers expressing GPNMB.