公开(公告)号：US10239873B2

公开(公告)日：2019-03-26

申请号：US15080068

申请日：2016-03-24

Applicant: GREEN CROSS CORPORATION

Inventor： Soongyu Choi ,  Kwang-Seop Song ,  Hee Jeong Seo ,  Sang-ho Ma ,  Eun-Jung Park ,  Younggyu Kong ,  So Ok Park ,  Kisoo Park ,  Ickhwan Son ,  Min Ju Kim ,  Man-Young Cha ,  Mi-Soon Kim ,  Sang Mi Kang ,  Dong Hyuk Jang ,  Jangwon Hong

IPC: C07D471/04 ,  C07D519/00 ,  C07D487/04

Abstract: Provided are 7-azaindole or 4,7-diazaindole derivatives as an IKKε (I-kappa-B kinase epsilon) and TBK1 (TANK-binding kinase 1) inhibitor. The 7-azaindole or 4,7-diazaindole derivative effectively inhibits IKKε and TBK1, and thus is useful not only as an anticancer agent for the treatment of various cancers including colorectal cancer, breast cancer, CNS cancer, colon cancer, non-small cell lung cancer, kidney cancer, prostate cancer, ovarian cancer, uterus cancer, stomach cancer, liver cancer, skin cancer, lung cancer, brain cancer, bladder cancer, esophageal cancer, pancreatic cancer, thyroid cancer, head and neck cancer, squamous cell carcinoma, osteosarcoma, B-cell or T-cell lymphoma, acute or chronic leukemia and multiple myeloma, but as a therapeutic agent for chronic inflammation.

公开(公告)号：US10294207B2

公开(公告)日：2019-05-21

申请号：US15083503

申请日：2016-03-29

Applicant: GREEN CROSS CORPORATION

Inventor： Soongyu Choi ,  Kisoo Park ,  Hee Jeong Seo ,  Eun-Jung Park ,  Younggyu Kong ,  Ickhwan Son ,  Sang-ho Ma ,  Kwang-Seop Song ,  Min Ju Kim ,  So Ok Park ,  Man-Young Cha ,  Mi-Soon Kim ,  Sang Mi Kang ,  Dong Hyuk Jang ,  Jangwon Hong

IPC: C07D231/56 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D495/04 ,  C07D409/04 ,  C07D417/12

Abstract: Provided is pyrazole derivatives as a TNIK (Traf2- and NCK-interacting kinase), IKKε (I-kappa-B kinase epsilon) and TBK1 (TANK-binding kinase 1) inhibitor; the pyrazole derivative according to the present invention effectively inhibits TNIK, IKKε and TBK1, and thus is useful not only as an anticancer agent for the treatment of various cancers including colorectal cancer, breast cancer, CNS cancer, colon cancer, non-small cell lung cancer, kidney cancer, prostate cancer, ovarian cancer, uterus cancer, stomach cancer, liver cancer, skin cancer, lung cancer, brain cancer, bladder cancer, esophageal cancer, pancreatic cancer, thyroid cancer, head and neck cancer, squamous cell carcinoma, osteosarcoma, B-cell or T-cell lymphoma, acute or chronic leukemia and multiple myeloma, but as a therapeutic agent for chronic inflammation.