公开(公告)号：US20180127733A9

公开(公告)日：2018-05-10

申请号：US15223647

申请日：2016-07-29

Applicant: GREEN CROSS CORPORATION

Inventor： Sy LEE ,  Sung-Ick PARK

IPC: C12N9/16

CPC classification number: C12N9/16 ,  A61K38/00 ,  C12Y301/06013

Abstract: Provided is a modified iduronate-2-sulfatase (IDS) gene constructed by inserting the nucleotide of SEQ ID NO: 2 into a wild-type IDS gene. In addition to being negatively charged, the improved IDS enzyme encoded by the modified gene exhibits a sufficient retention time in blood to target the bone, so that it is more effective for treating Hunter syndrome.

公开(公告)号：US20180030424A1

公开(公告)日：2018-02-01

申请号：US15223647

申请日：2016-07-29

Applicant: GREEN CROSS CORPORATION

Inventor： Sy LEE ,  Sung-Ick PARK

IPC: C12N9/16

CPC classification number: C12N9/16 ,  A61K38/00 ,  C12Y301/06013

Abstract: Provided is a modified iduronate-2-sulfatase (IDS) gene constructed by inserting the nucleotide of SEQ ID NO: 2 into a wild-type IDS gene. In addition to being negatively charged, the improved IDS enzyme encoded by the modified gene exhibits a sufficient retention time in blood to target the bone, so that it is more effective for treating Hunter syndrome.