公开(公告)号：US11406694B2

公开(公告)日：2022-08-09

申请号：US16333675

申请日：2016-10-24

Applicant: GRIFFITH UNIVERSITY

Inventor： Michael Good ,  Danielle Stanisic ,  Leanne Low

IPC: A61K39/002 ,  A61K39/018 ,  A61P33/06 ,  A61K31/65 ,  A61K39/015 ,  A61P33/02 ,  A01K67/027 ,  A61K31/435 ,  A61K31/7056 ,  A61K39/00

Abstract: Apicomplexan parasites or red blood cells infected with apicomplexan parasites are administered to an animal in combination with a delayed death agent that initially allows parasite replication but subsequently kills the apicomplexan parasites. This allows the elicitation of an immune response by the animal while preventing the parasites producing a serious infection of the animal. The apicomplexan parasites may be malaria or babesia parasites. The delayed death agent may be a tetracycline class antibiotic, a macrolide antibiotic or a lincosamide antibiotic.