公开(公告)号：US20220372459A1

公开(公告)日：2022-11-24

申请号：US17827072

申请日：2022-05-27

Applicant: GRIFFITH UNIVERSITY ,  THE UNIVERSITY OF ADELAIDE

Inventor： Michael Paul Jennings ,  Christopher Day ,  Adrienne Webster Paton ,  James Cleland Paton

IPC: C12N9/52 ,  C07K16/40 ,  G01N33/574

Abstract: A mutant subtilase cytotoxin B subunit protein is provided which can bind glycans having α2-3-linked N-glycolylneuraminic acid and glycans having α2-6-linked N-glycolylneuraminic acid. The mutant SubB protein has deletions of one or more of the amino acid sequence TTSTE and has a previously undescribed ability to bind glycans having α2-6-linked N-glycolylneuraminic acid, while not losing the ability to bind glycans having α2-3-linked N-glycolylneuraminic acid.

公开(公告)号：US11371033B2

公开(公告)日：2022-06-28

申请号：US16348732

申请日：2017-11-09

Applicant: GRIFFITH UNIVERSITY ,  THE UNIVERSITY OF ADELAIDE

Inventor： Michael Paul Jennings ,  Christopher Day ,  Adrienne Webster Paton ,  James Cleland Paton

IPC: C12N9/52 ,  C07K16/40 ,  G01N33/574 ,  A61K38/00

Abstract: A mutant subtilase cytotoxin B subunit protein is provided which can bind glycans having α2-3-linked N-glycolylneuraminic acid and glycans having α2-6-linked N-glycolylneuraminic acid. The mutant SubB protein has deletions of one or more of the amino acid sequence TTSTE and has a previously undescribed ability to bind glycans having α2-6-linked N-glycolylneuraminic acid, while not losing the ability to bind glycans having α2-3-linked N-glycolylneuraminic acid.