公开(公告)号：US10398657B2

公开(公告)日：2019-09-03

申请号：US15243271

申请日：2016-08-22

申请人： Gruenenthal GmbH

发明人： Klaus Schiene ,  Ilona Steigerwald ,  Michel Hamon ,  Johannes Schneider ,  Silvia Reinartz ,  Ulrich Jahnel ,  Thomas Tzschentke

IPC分类号： A61K31/137 ,  A61K9/00 ,  A61P25/04

摘要： The use of tapentadol in the treatment of pain and/or pain chronification in a subject suffering from pain chronification and/or in the treatment of pain and inhibition of pain chronification in a subject suffering from pain and at risk of pain chronification, as well as the use of tapentadol for the treatment or inhibition of migraine.

公开(公告)号：US09980927B2

公开(公告)日：2018-05-29

申请号：US15470385

申请日：2017-03-27

申请人： Gruenenthal GmbH

发明人： Ilona Steigerwald ,  Ulrich Jahnel ,  Thomas Tzschentke

IPC分类号： A61K31/137 ,  A61K9/00

CPC分类号： A61K31/137 ,  A61K9/0053

摘要： The use of tapentadol (i) in the treatment of pain in a subject suffering from depression and/or from anxiety, and/or (ii) in the treatment or the inhibition of depression or anxiety.

公开(公告)号：US10471079B2

公开(公告)日：2019-11-12

申请号：US15175564

申请日：2016-06-07

申请人： GRUENENTHAL GmbH

发明人： Klaus Schiene ,  Guenter Haase ,  Babette-Yvonne Koegel ,  Elmar Friderichs ,  Ulrich Jahnel

IPC分类号： A61K31/635 ,  A61K31/135 ,  A61K31/341 ,  A61K31/415 ,  A61K31/137 ,  A61K31/365

摘要： Combinations of certain analgesics with COX-II inhibitors, related pharmaceutical compositions, including advantageous galenical forms containing these combinations, and the use of such combinations in methods of treatment, in particular for the treatment of pain.