公开(公告)号：US20250069687A1

公开(公告)日：2025-02-27

申请号：US18439682

申请日：2024-02-12

Applicant: GUARDANT HEALTH, INC.

Inventor： Andrew M. GROSS ,  Hao WANG ,  Denis TOLKUNOV ,  Colby JENKINS ,  Sara WIENKE ,  Catalin BARBACIORU ,  Han-Yu CHUANG

IPC: G16B20/10 ,  G16B40/20

Abstract: Described herein are methods and compositions related to whole gene duplication (WGD). Methods are described for detecting and determining the presence of WGD in a sample, including cell free nucleic acids derived from a subject, such as a liquid sample (e.g., blood, plasma), as well as chromosomal instability and genomic alterations. In various embodiments, the aforementioned methods are used in diagnosis, prognosis and treatment. In other embodiments, processing of samples characterized by WGD is described to confer increased accuracy and precision of detection.