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    METHOD FOR MANUFACTURING MULTI-FUNCTIONAL BIO-MATERIAL CONJUGATE USING TWO KINDS OF PARTICLE, AND MULTI-FUNCTIONAL BIO-MATERIAL CONJUGATE MANUFACTURED BY MEANS OF SAME
    1.
    发明申请
    METHOD FOR MANUFACTURING MULTI-FUNCTIONAL BIO-MATERIAL CONJUGATE USING TWO KINDS OF PARTICLE, AND MULTI-FUNCTIONAL BIO-MATERIAL CONJUGATE MANUFACTURED BY MEANS OF SAME 有权
    使用两种颗粒制造多功能生物材料共混物的方法和由其制造的多功能生物材料共混物

    公开(公告)号：US20140272945A1

    公开(公告)日：2014-09-18

    申请号：US14351291

    申请日：2012-10-12

    申请人： GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

    发明人： Min-Gon Kim ,  Yun Ju Sung ,  Ju Young Byun ,  Young-Kyoung Oh ,  Hyou-Arm Joung

    IPC分类号： G01N33/543 ,  G01N33/58

    CPC分类号： G01N33/54346 ,  B82Y15/00 ,  B82Y40/00 ,  G01N33/54333 ,  G01N33/569 ,  G01N33/587 ,  Y10S977/774

    摘要： Disclosed herein are a method for manufacturing a multi-functional bio-material conjugate used as a biosensor for detecting microorganisms, and the like, and a multi-functional bio-material conjugate manufactured by means of the same. The method for manufacturing a multi-functional bio-material conjugate includes: (a) coating a first nanoparticle having magnetic or fluorescent characteristics with protein; (b) manufacturing a conjugate by adsorbing a second nanoparticle having metallic characteristics onto the first nanoparticle coated with protein; and (c) manufacturing the multi-functional bio-material conjugate by adsorbing a bio-material onto the conjugate. The method for manufacturing a multi-functional bio-material conjugate according to the present invention may prevent precipitation of the nanoparticles, easily immobilize the bio-material, and manufacture a bio-material conjugate having multiple functions, by using two kinds of the particles. In addition, the multi-functional bio-material conjugate manufactured by the present method may be used to detect microorganisms at up to a concentration of 101 cfu.

    摘要翻译： 本文公开了一种制造用于检测微生物的生物传感器等的多功能生物材料结合体的方法和利用其制造的多功能生物材料共轭体。 制造多功能生物材料缀合物的方法包括：（a）用蛋白质涂覆具有磁性或荧光特性的第一纳米颗粒; （b）通过将具有金属特性的第二纳米颗粒吸附到涂覆有蛋白质的第一纳米颗粒上来制备缀合物; 和（c）通过将生物材料吸附到缀合物上制备多功能生物材料缀合物。 根据本发明的制备多功能生物材料结合物的方法可以通过使用两种颗粒来防止纳米颗粒的沉淀，容易地使生物材料固定，并制造具有多种功能的生物材料共轭物。 此外，通过本方法制造的多功能生物材料缀合物可以用于以高达101cfu的浓度检测微生物。