公开(公告)号：US11739044B2

公开(公告)日：2023-08-29

申请号：US17183324

申请日：2021-02-23

Applicant: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.

Inventor： Ming-Hsi Chuang ,  Lin-Hsiang Chuang ,  Ming-Hsuan Lu ,  Wen-Peng Shen ,  Yun-Chen Lin ,  Chi-Hsuan Chuang

IPC: C07C51/09 ,  C07C51/42 ,  C07C59/52

CPC classification number: C07C51/09 ,  C07C51/42 ,  C07C59/52

Abstract: The present invention relates to a method for synthesizing artepillin C and a synthetic method for synthesizing an intermediate compound for use in preparing artepillin C. The structural formula of artepillin C is shown in the following formula (IV), and the intermediate compound is shown in the following formula (II). The synthesis method includes the following steps: a first reaction step: in the presence of a base initiator, a compound A shown in formula I and 3,3-dimethylallyl bromide are mixed, the reaction continues for a first reaction time and is stopped to generate an intermediate of artepillin C shown in formula II; and a second reaction step: the intermediate of artepillin C is dissolved in an aqueous alcohol solution and then mixed with an alkali metal salt, and the reaction continues for a second reaction time to generate artepillin C.

公开(公告)号：US20220098139A1

公开(公告)日：2022-03-31

申请号：US17183324

申请日：2021-02-23

Applicant: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.

Inventor： Ming-Hsi Chuang ,  Lin-Hsiang Chuang ,  Ming-Hsuan Lu ,  Wen-Peng Shen ,  Yun-Chen Lin ,  Chi-Hsuan Chuang

IPC: C07C51/09 ,  C07C51/42

Abstract: The present invention relates to a method for synthesizing artepillin C and a synthetic method for synthesizing an intermediate compound for use in preparing artepillin C. The structural formula of artepillin C is shown in the following formula (IV), and the intermediate compound is shown in the following formula (II). The synthesis method includes the following steps: a first reaction step: in the presence of a base initiator, a compound A shown in formula I and 3,3-dimethylallyl bromide are mixed, the reaction continues for a first reaction time and is stopped to generate an intermediate of artepillin C shown in formula II; and a second reaction step: the intermediate of artepillin C is dissolved in an aqueous alcohol solution and then mixed with an alkali metal salt, and the reaction continues for a second reaction time to generate artepillin C.