公开(公告)号：US20080119548A1

公开(公告)日：2008-05-22

申请号：US10593090

申请日：2005-03-18

申请人： Gabrielle V. Ronnett ,  Frankcis P. Kuhajda ,  Jagan N. Thupari ,  Leslie E. Landree ,  Timothy H. Moran ,  Eun-Kyoung Kim

发明人： Gabrielle V. Ronnett ,  Frankcis P. Kuhajda ,  Jagan N. Thupari ,  Leslie E. Landree ,  Timothy H. Moran ,  Eun-Kyoung Kim

IPC分类号： A61K31/341 ,  A61P3/04

CPC分类号： A61K31/34 ,  A61K31/70

摘要： Obesity is a worldwide health issue, affecting children and adults in developed and developing countries. Obesity is a disorder of both energy metabolism and appetite regulation, and may be understood as a dysfunction of energy balance. Applicants have found a means for regulating food intake by a subject by administering a compound to the subject which affects neuronal energy balance. Applicants have found a means for regulating food intake by a subject administering a compound to the subject which targets the activity of AMPK, in particular inhibiting activation, in particular hypothalamic. Applicants have also found a method of inducing weight loss in a subject by decreasing the subjects appetite by administering a compound to the subject which increases the subject's neuronal energy balance.

摘要翻译： 肥胖是世界卫生问题，影响发达国家和发展中国家的儿童和成人。 肥胖是能量代谢和食欲调节的障碍，可以理解为能量平衡的功能障碍。 申请人已经发现通过向受试者施用影响神经元能量平衡的化合物来调节受试者的食物摄取的方法。 申请人已经找到一种方法来调节受试者施用靶向AMPK活性的化合物，特别是抑制活化，特别是下丘脑的化合物的摄食。 申请人还发现通过向受试者施用增加受试者的神经元能量平衡的化合物，通过降低受试者的食欲来诱导受试者体重减轻的方法。