公开(公告)号：US08802125B2

公开(公告)日：2014-08-12

申请号：US11996348

申请日：2006-07-21

申请人： Gaetano Marenzi ,  Adele Bolognese ,  Luigi Califano ,  Antonio Calignano ,  Umberto Costantino ,  Gilberto Sammartino ,  Vittoria Vittoria

发明人： Gaetano Marenzi ,  Adele Bolognese ,  Luigi Califano ,  Antonio Calignano ,  Umberto Costantino ,  Gilberto Sammartino ,  Vittoria Vittoria

IPC分类号： A61K9/00 ,  A61K47/30 ,  A61K31/196 ,  A61K31/335 ,  A61P43/00

CPC分类号： A61L17/005 ,  A61K9/143 ,  A61K9/70 ,  A61K9/7007 ,  A61K47/52 ,  A61K47/6953 ,  A61L27/306 ,  A61L27/34 ,  A61L27/446 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/252 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/428 ,  A61L2400/12 ,  C08L67/04

摘要： The invention concerns a system for biocompatible drug release comprising: (i) a polymer matrix; (ii) an inorganic component located inside said matrix and characterized by a lamellar structure with a net positive or negative charge able to intercalate (iii) a pharmacologically active principle into said lamellar structure, by establishing an ionic type of bond with it and thereby obtaining an intercalation compound. The preparation process for the release system comprises the stages of: treating the lamellar solid in such a way as to give it a net positive or negative charge, then combining it with the chosen active principle, also in an ionic form, to obtain an intercalation compound which is then mixed with the polymer matrix. The release system can be employed in making medical devices, like sutures, membranes, osteosynthesis plaques, multilayered devices, gels and drug delivery systems.

摘要翻译： 本发明涉及用于生物相容性药物释放的系统，其包括：（i）聚合物基质; （ii）位于所述基质内的无机组分，其特征在于具有净正电荷或负电荷的层状结构，其能够（iii）药理活性成分插入所述层状结构中，通过与其形成离子型键，从而获得 插层化合物。 释放系统的制备方法包括以下阶段：以这样的方式处理层状固体，使其具有净正电荷或负电荷，然后将其与所选择的活性成分结合，也以离子形式，以获得插层 化合物，然后与聚合物基质混合。 释放系统可以用于制造医疗装置，例如缝线，膜，骨接合板，多层装置，凝胶和药物递送系统。

公开(公告)号：US20080299202A1

公开(公告)日：2008-12-04

申请号：US11996348

申请日：2006-07-21

申请人： Gaetano Marenzi ,  Adele Bolognese ,  Luigi Califano ,  Antonio Calignano ,  Umberto Costantino ,  Gilberto Sammartino ,  Vittoria Vittoria

发明人： Gaetano Marenzi ,  Adele Bolognese ,  Luigi Califano ,  Antonio Calignano ,  Umberto Costantino ,  Gilberto Sammartino ,  Vittoria Vittoria

IPC分类号： A61K9/00 ,  A61K47/30 ,  A61K31/196 ,  A61K31/335 ,  A61P43/00

CPC分类号： A61L17/005 ,  A61K9/143 ,  A61K9/70 ,  A61K9/7007 ,  A61K47/52 ,  A61K47/6953 ,  A61L27/306 ,  A61L27/34 ,  A61L27/446 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/252 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/428 ,  A61L2400/12 ,  C08L67/04

摘要： The invention concerns a system for biocompatible drug release comprising: (i) a polymer matrix; (ii) an inorganic component located inside said matrix and characterized by a lamellar structure with a net positive or negative charge able to intercalate (iii) a pharmacologically active principle into said lamellar structure, by establishing an ionic type of bond with it and thereby obtaining an intercalation compound. The preparation process for the release system comprises the stages of: treating the lamellar solid in such a way as to give it a net positive or negative charge, then combining it with the chosen active principle, also in an ionic form, to obtain an intercalation compound which is then mixed with the polymer matrix. The release system can be employed in making medical devices, like sutures, membranes, osteosynthesis plaques, multilayered devices, gels and drug delivery systems.

摘要翻译： 本发明涉及用于生物相容性药物释放的系统，其包括：（i）聚合物基质; （ii）位于所述基质内的无机组分，其特征在于具有净正电荷或负电荷的层状结构，其能够（iii）药理活性成分插入所述层状结构中，通过与其形成离子型键，从而获得 插层化合物。 释放系统的制备方法包括以下阶段：以这样的方式处理层状固体，使其具有净正电荷或负电荷，然后将其与所选择的活性成分结合，也以离子形式，以获得插层 化合物，然后与聚合物基质混合。 释放系统可以用于制造医疗装置，例如缝线，膜，骨接合板，多层装置，凝胶和药物递送系统。