公开(公告)号：US20230125962A1

公开(公告)日：2023-04-27

申请号：US18145780

申请日：2022-12-22

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： Faisal ZAIDI ,  Sebastien OUCHOUCHE

IPC: A61N1/372 ,  A61K31/56 ,  A61N1/05 ,  A61N1/375

Abstract: An extravascular neural interface is disclosed containing electrodes for neurostimulation of the vessel. The devices are housed in flexible substrates, each substrate having a spinal portion for routing leads/conductors into the device for connection to the electrodes. Extending from opposite sides of the spinal portion is a self-sizing inner flap that supports and positions the electrodes to be inward facing, i.e., extravascular designs, and one more rigid outer flap. The electrodes may be flexible multifilar coil electrodes.

公开(公告)号：US20220257932A1

公开(公告)日：2022-08-18

申请号：US17739897

申请日：2022-05-09

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： Faisal ZAIDI ,  Sebastien OUCHOUCHE

IPC: A61N1/05

Abstract: An extravascular neural interface is disclosed including a device containing electrodes for neurostimulation of a vessel. The devices are housed in flexible substrates forming two flaps, an inner flap having a spinal portion for routing leads/conductors into the device for connection to the electrodes and an outer flap that overlaps the inner flap. The inner flap supports and positions the electrodes to be inward facing, i.e., extravascular designs. The electrodes may be circular or elliptical and include a plurality of wings for securing the electrodes within a flap.

公开(公告)号：US20220193400A1

公开(公告)日：2022-06-23

申请号：US17594622

申请日：2020-04-24

Applicant: Faisal ZAIDI ,  GALVANI BIOELECTRONICS LIMITED

Inventor： Faisal ZAIDI

IPC: A61N1/05 ,  A61N1/375

Abstract: A neuromodulation system is described in which electrodes are mounted within a neural interface device configured to include elastic self-pulsatile or IPG-controlled pneumatic/hydraulic collars in a distal end of the system. One or more electrodes are mounted in each collar. Each collar is connected to an implanted pulse generator (IPG) at the proximal end of the neuromodulation system via a lead body that includes pneumatic/hydraulic lines to the collars and electrical wiring to the electrodes. Gas or fluid pressure supplied to each collar can be controlled by one or more precision step motors inside the IPG. Proximal connectors to the lead body have one or more gas or liquid (biocompatible) reservoirs whose pressure is individually or collectively controlled by the one or more precision motors inside the IPG. The IPG can drive one common or multiple independent precision motors lined around each reservoir to drive one or more collars in the neural interface device.

公开(公告)号：US20210085965A1

公开(公告)日：2021-03-25

申请号：US16634626

申请日：2018-07-23

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： Faisal ZAIDI ,  Sebastien OUCHOUCHE

IPC: A61N1/05 ,  A61N1/375

Abstract: An extravascular or intravascular neural interface is disclosed containing electrodes for neurostimulation of the vessel. The devices are housed in flexible substrates formed from a multilumen tubing housing conductors for electrodes positioned in a distal serpentine shaped end of the device. The distal serpentine shaped end includes rows or strips of electrodes or coil electrodes.

公开(公告)号：US20230015707A1

公开(公告)日：2023-01-19

申请号：US17846379

申请日：2022-06-22

Applicant: Galvani Bioelectronics Limited

Inventor： Faisal ZAIDI ,  Sebastien OUCHOUCHE

IPC: A61N1/05 ,  A61N1/375

Abstract: An extravascular of intravascular neural interface is disclosed containing electrodes for neurostimulation of the vessel. The devices are housed in flexible substrates formed from a multilumen tubing housing conductors for electrodes positioned in a distal serpentine shaped end of the device. The distal serpentine shaped end includes rows or strips of electrodes or coil electrodes.

公开(公告)号：US20210178153A1

公开(公告)日：2021-06-17

申请号：US17248735

申请日：2021-02-05

Applicant: Galvani Bioelectronics Limited

Inventor： Faisal ZAIDI ,  Sabastien OUCHOUCHE ,  Paul MATTEUCCI

IPC: A61N1/05 ,  A61K9/00 ,  A61K31/56 ,  A61N1/36 ,  A61N1/375

Abstract: An extravascular or intravascular neural interface is disclosed comprising three C-ring portions, with at least two including an electrode, an electrode pair or an electrode array. The portions are formed of a flexible material that is configured to enable the portions to self-size to fit around or against a surface of a target vessel when the neural interface is released at a position along the target vessel. A spinal portion configured to house electrical conductors for the electrodes is connected to one or more portions. The portions may be spaced sufficient apart to permit radial expansion and contraction of a target vessel around or within which the neural interface is placed, to reduce never compression, open trench low-pressure unrestricted blood-flow, and to enhance fluid exchange with the target vessel. The portions may be arranged in a low helix angle forming at least two full turns.

公开(公告)号：US20210085964A1

公开(公告)日：2021-03-25

申请号：US16634632

申请日：2018-07-23

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： Faisal ZAIDI ,  Sebastien OUCHOUCHE

IPC: A61N1/05

Abstract: An extravascular neural interface is disclosed including a device containing electrodes for neurostimulation of a vessel. The devices are housed in flexible substrates forming two flaps, an inner flap having a spinal portion for routing leads/conductors into the device for connection to the electrodes and an outer flap that overlaps the inner flap. The inner flap supports and positions the electrodes to be inward facing, i.e., extravascular designs. The electrodes may be circular or elliptical and include a plurality of wings for securing the electrodes within a flap.

公开(公告)号：US20200230421A1

公开(公告)日：2020-07-23

申请号：US16634620

申请日：2018-07-23

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： Faisal ZAIDI ,  Sebastien OUCHOUCHE

IPC: A61N1/372 ,  A61N1/05 ,  A61N1/375 ,  A61K31/56

Abstract: An extravascular neural interface is disclosed containing electrodes for neurostimulation of the vessel. The devices are housed in flexible substrates, each substrate having a spinal portion for routing leads/conductors into the device for connection to the electrodes. Extending from opposite sides of the spinal portion is a self-sizing inner flap that supports and positions the electrodes to be inward facing, i.e., extravascular designs, and one more rigid outer flap. The electrodes may be flexible multifilar coil electrodes.

公开(公告)号：US20200230399A1

公开(公告)日：2020-07-23

申请号：US16619396

申请日：2018-07-23

Applicant: Galvani Bioelectronics Limited

Inventor： Faisal ZAIDI ,  Sabastien OUCHOUCHE ,  Paul MATTEUCCI, JR.

IPC: A61N1/05 ,  A61N1/36 ,  A61N1/375 ,  A61K9/00 ,  A61K31/56

Abstract: An extravascular or intravascular neural interface is disclosed and can include three C-ring portions, with at least two including an electrode, an electrode pair or an electrode array. The portions are formed of a flexible material that is configured to enable the portions to self-size to fit around or against a surface of a target vessel when the neural interface is released at a position along the target vessel. A spinal portion configured to house electrical conductors for the electrodes is connected to one or more portions. The portions may be spaced sufficient apart to permit radial expansion and contraction of a target vessel around or within which the neural interface is placed, to reduce nerve compression, open trench low-pressure unrestricted blood-flow, and to enhance fluid exchange with the target vessel. The portions may be arranged in a low helix angle forming at least two full turns.