公开(公告)号：US20250128063A1

公开(公告)日：2025-04-24

申请号：US18682265

申请日：2022-08-09

Applicant: Galvani Bioelectronics Limited

Inventor： Margarita J. Vervoordeldonk ,  Misha Luyer

IPC: A61N1/36 ,  A61N1/05

Abstract: Stimulation of the spleen and/or neural activity of one or more nerves supplying the spleen, such as a nerve associated with the splenic arterial neurovascular bundle, can decrease C-Reactive Protein (CRP) levels and post-operative surgical complications. The system for stimulating the spleen and/or neural activity of one or more nerves supplying the spleen for reducing post-operative surgical complications can include at least one transducer in signaling contact with the spleen and/or the one or more nerves; and at least one controller electrically coupled to the at least one transducer. The at least one controller can be configured to control the operation of the at least one transducer to apply a stimulating signal to the spleen and/or the one or more nerves. The stimulating signal may produce a change in a physiological parameter indicative of a target engagement of the nerves resulting in a reduction in C-reactive protein (CRP) plasma levels and/or Interleukin-6 (IL-6) plasma levels after surgery and reducing post-operative surgical complications and/or days in hospital.