公开(公告)号：US5919155A

公开(公告)日：1999-07-06

申请号：US374006

申请日：1995-01-18

申请人： Gary A. Lattin ,  J. Richard Gyory ,  Charles Albert ,  Scott Jay Gilbert

发明人： Gary A. Lattin ,  J. Richard Gyory ,  Charles Albert ,  Scott Jay Gilbert

IPC分类号： A61N1/30 ,  A61N1/32

CPC分类号： A61N1/044 ,  A61N1/30 ,  A61N1/303 ,  A61N1/325 ,  A61N1/0448 ,  Y10S439/909

摘要： A device (10) for the electrically assisted delivery of a therapeutic agent is described. The device (10) has rigid zones or regions (12, 14) which are physically connected by a flexible means (16) such as a web. The flexible means (16) permits the rigid zones (12, 14) to move independently with respect to each other while remaining physically connected or coupled. In a preferred embodiment, the rigid zones are physically and electronically coupled by the flexible means. In another embodiment, the device (500) comprises one or more rigid zones, the skin side of the rigid zone having a radius of curvature (520) which approximates that of the body site to which the device (500) is to be attached. A method of increasing the body surface conformability of an electrotransport device (50, 150, 170) is described. The method involves the step of intentionally placing rigid subcomponents (58, 36, 37) of the device in physically separate zones (52, 54; 152, 154, 156, 158; 172, 174, 176, 178) within the device. The rigid zones (52, 54; 152, 154, 156, 158; 172, 174, 176, 178) are separate and are coupled by flexible connector means (56, 62; 160, 162). In this manner, a conformable mosaic of rigid zones which comprises the device is created.

摘要翻译： 描述了用于电辅助递送治疗剂的装置（10）。 装置（10）具有刚性区域或区域（12,14），其通过诸如腹板的柔性装置（16）物理连接。 柔性装置（16）允许刚性区域（12,14）相对于彼此独立地移动，同时保持物理连接或联接。 在优选实施例中，刚性区域通过柔性装置物理地和电子地联接。 在另一个实施例中，装置（500）包括一个或多个刚性区域，刚性区域的皮肤侧具有近似于装置（500）所附着的身体部位的曲率半径（520）。 描述了增加电输送装置（50,150,170）的体表顺应性的方法。 该方法包括将装置的刚性子部件（58,36,37）有意地放置在装置内的物理上分离的区域（52,54; 152,154,156,158,172,174,176,178）中的步骤。 刚性区域（52,54; 152,154,156,158,172,174,176,178）是分开的并且通过柔性连接器装置（56,​​62; 160,162）联接。 以这种方式，创建包括该装置的刚性区域的一致的马赛克。

公开(公告)号：US07316680B2

公开(公告)日：2008-01-08

申请号：US11237489

申请日：2005-09-27

申请人： Scott Jay Gilbert

发明人： Scott Jay Gilbert

IPC分类号： A61K9/22

CPC分类号： A61K9/0024 ,  A61K9/0004

摘要： An implantable osmotically driven delivery system having a dynamic, two-way valve and a self-adjusting, variable geometry fluid flow channel. As pressure within the agent delivery system increases, the fluid channel narrows, thereby restricting flow. At exceptionally high pressures, the valve can be designed to close altogether at the orifice or delivery end, or it can provide a minimal leak path so that a maximum fluid flow is never exceeded. At zero or very low pressures, the valve will close completely at the beneficial agent reservoir end, isolating the beneficial agent formulation from external fluid infiltration and thereby eliminating diffusion of external fluid into the beneficial agent formulation.

摘要翻译： 一种植入式渗透驱动输送系统，其具有动态双向阀和自调节可变几何流体流动通道。 当药剂输送系统内的压力增加时，流体通道变窄，从而限制流动。 在非常高的压力下，阀门可以设计成在孔口或输送端处完全关闭，或者可以提供最小的泄漏路径，从而不会超过最大流体流量。 在零或非常低的压力下，阀将在有益剂储存器端完全闭合，将有益剂制剂与外部流体渗透隔离，从而消除外部流体扩散到有益剂制剂中。

公开(公告)号：US07014636B2

公开(公告)日：2006-03-21

申请号：US10302104

申请日：2002-11-21

申请人： Scott Jay Gilbert

发明人： Scott Jay Gilbert

IPC分类号： A61K9/22

CPC分类号： A61K9/0024 ,  A61K9/0004

摘要： An implantable osmotically driven delivery system having a dynamic, two-way valve and a self-adjusting, variable geometry fluid flow channel. As pressure within the agent delivery system increases, the fluid channel narrows, thereby restricting flow. At exceptionally high pressures, the valve can be designed to close altogether at the orifice or delivery end, or it can provide a minimal leak path so that a maximum fluid flow is never exceeded. At zero or very low pressures, the valve will close completely at the beneficial agent reservoir end, isolating the beneficial agent formulation from external fluid infiltration and thereby eliminating diffusion of external fluid into the beneficial agent formulation.

摘要翻译： 一种植入式渗透驱动输送系统，其具有动态双向阀和自调节可变几何流体流动通道。 当药剂输送系统内的压力增加时，流体通道变窄，从而限制流动。 在非常高的压力下，阀门可以设计成在孔口或输送端处完全关闭，或者可以提供最小的泄漏路径，从而不会超过最大流体流量。 在零或非常低的压力下，阀将在有益剂储存器端完全闭合，将有益剂制剂与外部流体渗透隔离，从而消除外部流体扩散到有益剂制剂中。