公开(公告)号：US06534283B1

公开(公告)日：2003-03-18

申请号：US09718783

申请日：2000-11-22

申请人： Geert Schmid-Schoenbein ,  Tony Hugli ,  Hiroshi Mitsuoka

发明人： Geert Schmid-Schoenbein ,  Tony Hugli ,  Hiroshi Mitsuoka

IPC分类号： C12Q137

CPC分类号： A61K38/55 ,  A61K31/00 ,  A61K31/24 ,  A61K31/245 ,  A61K38/063 ,  A61K2300/00

摘要： Shock is a life threatening complication in situations associated with trauma including burns, surgery, ischemia, sepsis, and other critical care applications. Shock is induced by pancreatic proteases when they are released into the small intestine when the tissue is compromised due to trauma. Administration of protease inhibitors into the small intestine, either orally, intraveneously, or by direct lavage, was demonstrated to prevent shock in rats as determined by both survival time and molecular and histological analysis.

摘要翻译： 在与包括烧伤，手术，缺血，败血症和其他关键护理应用在内的创伤相关的情况下，休克是一种威胁生命的并发症。 当胰腺蛋白酶由于创伤而被破坏时，胰腺蛋白酶被释放到小肠中时会引起冲击。 通过口服，静脉内或通过直接灌洗将蛋白酶抑制剂施用到小肠中，证明了通过存活时间和分子和组织学分析确定的大鼠休克。