公开(公告)号：US11827639B2

公开(公告)日：2023-11-28

申请号：US16626191

申请日：2018-06-28

Applicant: Genentech, Inc. ,  NewLink Genetics Corporation

Inventor： Zhonghua Pei ,  Brendan Parr ,  Wendy Liu ,  Richard Pastor ,  Lewis Gazzard ,  Firoz Jaipuri ,  Sanjeev Kumar ,  Hima Potturi ,  Guoshen Wu ,  Xingyu Lin ,  Yanyan Chu ,  Powai Yuen

IPC: C07D487/04 ,  A61K31/4188 ,  A61K31/438 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/437 ,  A61K31/4725 ,  A61K31/5377 ,  A61K45/06

CPC classification number: C07D487/04

Abstract: Presently provided are inhibitors of TD02 and IDO1 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2,3 dioxygenase and indoleamine 2,3-dioxygenase 1; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.

公开(公告)号：US11603373B2

公开(公告)日：2023-03-14

申请号：US16626219

申请日：2018-06-20

Applicant: Genentech, Inc.

Inventor： Zhonghua Pei ,  Richard Pastor ,  Lewis Gazzard ,  Brendan Parr ,  Wendy Liu ,  Rohan Mendonca ,  Guosheng Wu ,  Po-wai Yuen

IPC: C07D221/00 ,  C07D335/00 ,  C07D487/04 ,  C07D471/08 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00

Abstract: Presently provided are inhibitors of cellularly expressed TD02 and IDO1, and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2,3 dioxygenase and indoleamine 2,3-dioxygenase 1; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.

公开(公告)号：US10800780B2

公开(公告)日：2020-10-13

申请号：US16065397

申请日：2016-12-23

Applicant: Genentech, Inc. ,  NewLink Genetics Corporation

Inventor： Xingyu Lin ,  Po-wai Yuen ,  Rohan Mendonca ,  Brendan Parr ,  Richard Pastor ,  Zhonghua Pei ,  Lewis Gazzard ,  Firoz Jaipuri ,  Sanjeev Kumar ,  Xiaokai Li ,  Roheeth Pavana ,  Hima Potturi ,  Venkata Velvadapu ,  Jesse Waldo ,  Zuhui Zhang ,  Guosheng Wu ,  Benjamin Douglas Sellers

IPC: A61K31/4188 ,  A61K31/407 ,  A61K31/4035 ,  C07D487/04 ,  C07D519/00 ,  A61P35/00 ,  A61K45/06 ,  A61K38/16

Abstract: Presently provided are inhibitors of cellularly expressed TDO2 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2, 3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.

公开(公告)号：US20240132507A1

公开(公告)日：2024-04-25

申请号：US18496146

申请日：2023-10-27

Applicant: Genentech, Inc. ,  NewLink Genetics Corporation

Inventor： Zhonghua Pei ,  Brendan Parr ,  Wendy Liu ,  Richard Pastor ,  Lewis Gazzard ,  Firoz Jaipuri ,  Sanjeev Kumar ,  Hima Potturi ,  Guoshen Wu ,  Xingyu Lin ,  Yanyan Chu ,  Po-wai Yuen

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: Presently provided are inhibitors of TD02 and IDO1 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2,3 dioxygenase and indoleamine 2,3-dioxygenase 1; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.

公开(公告)号：US20200216456A1

公开(公告)日：2020-07-09

申请号：US16626191

申请日：2018-06-28

Applicant: Genentech, Inc. ,  NewLink Genetics Corporation

Inventor： Zhonghua Pei ,  Brendan Parr ,  Wendy Liu ,  Richard Pastor ,  Lewis Gazzard ,  Firoz Jaipuri ,  Sanjeev Kumar ,  Hima Potturi ,  Guoshen Wu ,  Xingyu Lin ,  Yanyan Chu ,  Powai Yuen

IPC: C07D487/04

Abstract: Presently provided are inhibitors of TD02 and IDOl and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2,3 dioxygenase and indoleamine 2,3-dioxygenase 1; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.

公开(公告)号：US20220306635A1

公开(公告)日：2022-09-29

申请号：US17068574

申请日：2020-10-12

Applicant: Genentech, Inc. ,  NewLink Genetics Corporation

Inventor： Xingyu Lin ,  Po-wai Yuen ,  Rohan Mendonca ,  Brendan Parr ,  Richard Pastor ,  Zhonghua Pei ,  Lewis Gazzard ,  Firoz Jaipuri ,  Sanjeev Kumar ,  Xiaokai Li ,  Roheeth Pavana ,  Hima Potturi ,  Venkata Velvadapu ,  Jesse Waldo ,  Zuhui Zhang ,  Guosheng Wu ,  Benjamin Douglas Sellers

IPC: C07D487/04 ,  A61P35/00 ,  A61K38/16 ,  A61K45/06 ,  C07D519/00

Abstract: Presently provided are inhibitors of cellularly expressed TD02 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2, 3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.

公开(公告)号：US20190016726A1

公开(公告)日：2019-01-17

申请号：US16065397

申请日：2016-12-23

Applicant: Genentech, Inc. ,  NewLink Genetics Corporation

Inventor： Xingyu Lin ,  Po-wai Yuen ,  Rohan Mendonca ,  Brendan Parr ,  Richard Pastor ,  Zhonghua Pei ,  Lewis Gazzard ,  Firoz Jaipuri ,  Sanjeev Kumar ,  Xiaokai Li ,  Roheeth Pavana ,  Hima Potturi ,  Venkata Velvadapu ,  Jesse Waldo ,  Zuhui Zhang ,  Guosheng Wu

IPC: C07D487/04 ,  A61P35/00 ,  C07D519/00 ,  A61K38/16

Abstract: Presently provided are inhibitors of cellularly expressed TDO2 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2, 3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.