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公开(公告)号：US10689447B2
公开(公告)日：2020-06-23
申请号：US13958318
申请日：2013-08-02
Applicant: Genentech, Inc.
Inventor： J. Michael Elliott , Justin Scheer
Abstract: Described herein are Fc variants and methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins). Heteromultimeric proteins may be capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.
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公开(公告)号：US11912773B2
公开(公告)日：2024-02-27
申请号：US16872974
申请日：2020-05-12
Applicant: Genentech, Inc.
Inventor： J. Michael Elliott , Justin Scheer
CPC classification number: C07K16/2863 , C07K16/244 , C07K16/247 , C07K16/468
Abstract: Described herein are Fc variants and methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins). Heteromultimeric proteins may be capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.
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公开(公告)号：US20200377604A1
公开(公告)日：2020-12-03
申请号：US16872974
申请日：2020-05-12
Applicant: Genentech, Inc.
Inventor： J. Michael Elliott , Justin Scheer
Abstract: Described herein are Fc variants and methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins). Heteromultimeric proteins may be capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.
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