公开(公告)号：US20240279283A1

公开(公告)日：2024-08-22

申请号：US18566257

申请日：2022-06-01

Applicant: Genentech, Inc.

Inventor： Christian Nathaniel CUNNINGHAM ,  Jian Mehr-Dean PAYANDEH ,  Steven Thomas RUTHERFORD ,  Kelly Marie Colvin STOREK ,  Patrick C. REID ,  Hayato YANAGIDA ,  Junichi NISHIKAWA

IPC: C07K7/64 ,  A61K38/12 ,  A61K45/06

CPC classification number: C07K7/64 ,  A61K38/12 ,  A61K45/06

Abstract: Provided herein are antibacterial compound peptides active against Gram-negative bacteria. In various embodiments, the compounds act by inhibition of BAM A membrane protein. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.