公开(公告)号：US20140377276A1

公开(公告)日：2014-12-25

申请号：US14163891

申请日：2014-01-24

Applicant: Genentech, Inc.

Inventor： Napoleone Ferrara ,  Kyung Jin Kim

IPC: C07K16/22 ,  A61K38/18

CPC classification number: C07K16/22 ,  A61K38/179 ,  A61K38/1866 ,  A61K2039/505 ,  C07K14/475 ,  C07K16/2863 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/30

Abstract: The present invention provides human vascular endothelial cell growth factor (hVEGF) antagonists, including monoclonal antibodies, hVEGF receptors, and hVEGF variants that are useful for the treatment of age-related macular degeneration, and other diseases and disorders characterized by undesirable or excessive neovascularization.

Abstract translation: 本发明提供了人类血管内皮细胞生长因子（hVEGF）拮抗剂，包括可用于治疗年龄相关性黄斑变性的单克隆抗体，hVEGF受体和hVEGF变体以及以不良或过度新生血管形成为特征的其它疾病和病症。