公开(公告)号：US20240248092A1

公开(公告)日：2024-07-25

申请号：US18590121

申请日：2024-02-28

Applicant: Genentech, Inc.

Inventor： Marcin Kowantez ,  Daniel Shin-Yu Chen ,  Hartmut Koeppen

IPC: G01N33/574 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  C07K16/28 ,  C07K16/30 ,  C12Q1/6886 ,  G06Q30/0241 ,  G06Q30/0251

CPC classification number: G01N33/57492 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/2827 ,  C07K16/30 ,  C12Q1/6886 ,  G01N33/574 ,  G06Q30/0241 ,  G06Q30/0251 ,  A61K2039/505 ,  C07K2317/73 ,  C07K2317/76 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N2333/70532

Abstract: Provided herein are biomarkers for the treatment of pathological conditions, such as cancer, and method of using PD-1/PD-L1 pathway antagonists. In particular, provided are biomarkers for patient selection and prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.