公开(公告)号：US11034698B2

公开(公告)日：2021-06-15

申请号：US16715933

申请日：2019-12-16

申请人： Genentech, Inc.

发明人： Marian C. Bryan ,  Steven Do ,  Joy Drobnick ,  Alberto Gobbi ,  Tamiko Katsumoto ,  James Richard Kiefer, Jr. ,  Jun Liang ,  Naomi S. Rajapaksa ,  Yongsheng Chen ,  Liqiang Fu ,  Kwong Wah Lai ,  Zhiguo Liu ,  John Wai ,  Fei Wang

IPC分类号： C07D487/04 ,  C07D519/00

摘要： Compounds of Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, Formula VIII, and methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

公开(公告)号：US11434250B2

公开(公告)日：2022-09-06

申请号：US16863741

申请日：2020-04-30

申请人： Genentech, Inc.

发明人： Marian C. Bryan ,  Joy Drobnick ,  James Richard Kiefer, Jr. ,  Aleksandr Kolesnikov ,  Naomi S. Rajapaksa

IPC分类号： C07D519/00 ,  A61P1/04 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P19/06 ,  A61P25/00 ,  A61P25/04 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02 ,  A61P37/06 ,  A61P43/00

摘要： Compounds of Formula I and methods of use as Interleukin-1 Receptor Associated Kinase 4 (IRAK4) inhibitors are described herein.

公开(公告)号：US20230016791A1

公开(公告)日：2023-01-19

申请号：US17821851

申请日：2022-08-24

申请人： Genentech, Inc.

发明人： Mark Edward Zak ,  Naomi S. Rajapaksa ,  Yun-Xing Cheng ,  Jessica Marie Grandner ,  Daniel G.M. Shore ,  Marian C. Bryan

IPC分类号： C07D487/04 ,  A61P11/06 ,  A61K9/00 ,  A61K9/19

摘要： wherein R1, R2, R3, R4, R5 and R6 are as defined herein, and salts thereof that are useful as JAK kinse inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

公开(公告)号：US11453671B2

公开(公告)日：2022-09-27

申请号：US16902499

申请日：2020-06-16

申请人： Genentech, Inc.

发明人： Mark Edward Zak ,  Naomi S. Rajapaksa ,  Yun-Xing Cheng ,  Jessica Grandner ,  Daniel G. M. Shore ,  Marian C. Bryan

IPC分类号： A61K31/519 ,  C07D487/04 ,  A61P11/06 ,  A61K9/00 ,  A61K9/19

摘要： Compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined herein, and salts thereof that are useful as JAK kinse inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

公开(公告)号：US20230167123A1

公开(公告)日：2023-06-01

申请号：US18063575

申请日：2022-12-08

申请人： Genentech, Inc.

发明人： Mark Edward Zak ,  Naomi S. Rajapaksa ,  Yun-Xing Cheng ,  Jessica Grandner ,  Daniel G.M. Shore ,  F. Anthony Romero ,  Marian C. Bryan

IPC分类号： C07D487/04 ,  A61P37/06

CPC分类号： C07D487/04 ,  A61P37/06

摘要： Compounds of formula (I)




wherein R1, R2, R3, R4, R5 and R6 are as defined herein, and salts thereof, that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

公开(公告)号：US20220106322A1

公开(公告)日：2022-04-07

申请号：US17644742

申请日：2021-12-16

申请人： Genentech, Inc.

发明人： Mark Edward Zak ,  Naomi S. Rajapaksa ,  Yun-Xing Cheng ,  Wei Li ,  Daniel G.M. Shore ,  F. Anthony Romero ,  Marian C. Bryan

IPC分类号： C07D487/04 ,  C07D519/00

摘要： Compounds and salts thereof that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

公开(公告)号：US10899774B2

公开(公告)日：2021-01-26

申请号：US16715959

申请日：2019-12-16

申请人： Genentech, Inc.

发明人： Marian C. Bryan ,  Joy Drobnick ,  Alberto Gobbi ,  Tamiko Katsumoto ,  Naomi S. Rajapaksa ,  James Richard Kiefer, Jr.

IPC分类号： C07D498/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D513/04

摘要： Compounds of Formula 0, and stereoisomers and pharmaceutically acceptable salts thereof, as well as methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

公开(公告)号：US10899772B2

公开(公告)日：2021-01-26

申请号：US16715997

申请日：2019-12-16

申请人： Genentech, Inc.

发明人： Marian C. Bryan ,  Steven Do ,  Tamiko Katsumoto ,  Jun Liang ,  Naomi S. Rajapaksa ,  James Richard Kiefer, Jr. ,  Liqiang Fu

IPC分类号： C07D487/04 ,  C07D413/14 ,  C07D471/04 ,  C07D495/04

摘要： Compounds of Formula 0, and stereoisomers and pharmaceutically acceptable salts thereof, as well as methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.