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公开(公告)号：US11485975B2
公开(公告)日：2022-11-01
申请号：US16987030
申请日：2020-08-06
Applicant: Genentech, Inc.
Inventor： Peter Hagedorn , Marianne L. Jensen , Lukasz Kielpinski , Amy Easton , Benny Chih
IPC: C12N15/11 , C12N15/113
Abstract: The present invention relates to oligonucleotides that are complementary to and modulate the expression of TMEM106B. The present invention further relates to conjugates of the oligonucleotide and pharmaceutical compositions and methods for treatment of neurological disorders using the oligonucleotide.
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