公开(公告)号：US20230250103A1

公开(公告)日：2023-08-10

申请号：US18299622

申请日：2023-04-12

Applicant: Genentech, Inc.

Inventor： Danial BEAUDRY ,  Theresa CRAVILLION ,  Francis GOSSELIN ,  Ngiap-Kie LIM ,  Sushant MALHOTRA ,  Qingping TIAN ,  Haiming ZHANG ,  Alexander GMEHLING ,  Alec FETTES ,  Stephan BACHMANN

IPC: C07D487/04 ,  B01J31/24

CPC classification number: C07D487/04 ,  B01J31/2409 ,  B01J31/2414 ,  B01J2231/40 ,  B01J2531/824 ,  C07B2200/09

Abstract: Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3′-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4′]bipyridinyl-2′-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided. Methods for preparing tricyclic lactam compounds are also provided.

公开(公告)号：US20210079004A1

公开(公告)日：2021-03-18

申请号：US17102086

申请日：2020-11-23

Applicant: Genentech, Inc.

Inventor： Danial BEAUDRY ,  Theresa CRAVILLION ,  Francis GOSSELIN ,  Ngiap-Kie LIM ,  Sushant MALHOTRA ,  Qingping TIAN ,  Haiming ZHANG ,  Alexander GMEHLING ,  Alec FETTES ,  Stephan BACHMANN

IPC: C07D487/04 ,  B01J31/24

Abstract: Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3′-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4′]bipyridinyl-2′-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided. Methods for preparing tricyclic lactam compounds are also provided.

公开(公告)号：US20200062762A1

公开(公告)日：2020-02-27

申请号：US16460889

申请日：2019-07-02

Applicant: Genentech, Inc.

Inventor： Danial BEAUDRY ,  Theresa CRAVILLION ,  Francis GOSSELIN ,  Ngiap-Kie LIM ,  Sushant MALHOTRA ,  Qingping TIAN ,  Haiming ZHANG ,  Alexander GMEHLING ,  Alec FETTES ,  Stephan BACHMANN

IPC: C07D487/04 ,  B01J31/24

Abstract: Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3′-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4′]bipyridinyl-2′-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided. Methods for preparing tricyclic lactam compounds are also provided.

公开(公告)号：US20180230155A1

公开(公告)日：2018-08-16

申请号：US15841828

申请日：2017-12-14

Applicant: Genentech, Inc.

Inventor： Danial BEAUDRY ,  Theresa CRAVILLION ,  Francis GOSSELIN ,  Ngiap-Kie LIM ,  Sushant MALHOTRA ,  Qingping TIAN ,  Haiming ZHANG ,  Alexander GMEHLING ,  Alec FETTES ,  Stephan BACHMANN

IPC: C07D487/04 ,  B01J31/24

CPC classification number: C07D487/04 ,  B01J31/2409 ,  B01J31/2414 ,  B01J2231/40 ,  B01J2531/824 ,  C07B2200/09

Abstract: Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3′-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4′]bipyridinyl-2′-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided. Methods for preparing tricyclic lactam compounds are also provided.