公开(公告)号：US09890152B2

公开(公告)日：2018-02-13

申请号：US14745159

申请日：2015-06-19

Applicant: Genentech, Inc.

Inventor： Marian C. Bryan ,  Bryan Chan ,  Emily Hanan ,  Timothy Heffron ,  Hans Purkey ,  Richard Leonard Elliott ,  Robert Heald ,  Jamie Knight ,  Michael Lainchbury ,  Eileen M. Seward

IPC: C07D471/04 ,  C07D498/10 ,  A61K31/506 ,  A61K31/5377 ,  C07D498/08 ,  A61K31/541 ,  A61K31/538 ,  C07D491/107 ,  C07D519/00 ,  A61K31/5355 ,  A61K45/06

CPC classification number: C07D471/04 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/541 ,  A61K45/06 ,  C07D491/107 ,  C07D498/08 ,  C07D498/10 ,  C07D519/00

Abstract: This invention relates to novel compounds which are inhibitors of T790M containing EGFR mutants, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of cancer.