公开(公告)号：US20140199327A1

公开(公告)日：2014-07-17

申请号：US14211270

申请日：2014-03-14

Applicant: Genentech, Inc.

Inventor： Vishva M. Dixit ,  Dorothy M. French ,  Heather L. Maecker ,  Samuel A. Williams

IPC: G01N33/50

CPC classification number: G01N33/502 ,  G01N33/5011 ,  G01N33/5073 ,  G01N2333/948

Abstract: Provided herein are methods of promoting cell fate change, particularly differentiation of tumor cells, by inhibition of USP1, UAF1, and/or ID (e.g., ID1, ID2, and/or ID3).

Abstract translation: 本文提供通过抑制USP1，UAF1和/或ID（例如，ID1，ID2和/或ID3）促进细胞命运变化，特别是肿瘤细胞分化的方法。