公开(公告)号：US20250054631A1

公开(公告)日：2025-02-13

申请号：US18929486

申请日：2024-10-28

Applicant: Genentech, Inc.

Inventor： Yinghui GUAN ,  Shan LU ,  Yulei WANG ,  Alexander ABBAS

IPC: G16H50/20 ,  G16H20/17 ,  G16H30/40 ,  G16H50/70

Abstract: A method for hepatocellular carcinoma (HCC) subtype classification and treatment may include identifying, for a liver epithelial cell lineage, one or more features associated with the liver epithelial cell lineage. The one or more features may be designated as representative of a molecular subtype associated with hepatocellular carcinoma (HCC) such as, for example, a cholangio-like subtype, a hepatocyte-like subtype, or a progenitor-like subtype. A patient may be determined to exhibit the molecular subtype if these features are detected within the tumor sample of the patient. Moreover, treatment for the patient may be determined based on the molecular subtype exhibited by the patient. For example, treatment for the patient may include additional therapies, such as an GPC3/CD3 bi-specific antibody, to overcome subtype-specific resistance to combination immunotherapy associated with the progenitor-like subtype. Related systems and computer program products are also provided.