公开(公告)号：US20210338684A1

公开(公告)日：2021-11-04

申请号：US17370721

申请日：2021-07-08

Applicant: Genentech, Inc.

Inventor： Robert L. YAUCH ,  Xiaofen YE ,  Thomas E. JANUARIO

IPC: A61K31/5377 ,  A61P35/00 ,  A61K45/06 ,  C12Q1/6886

Abstract: The present invention provides diagnostic and therapeutic methods for cancer. The invention provides methods of determining whether a patient having a cancer is likely to respond to treatment comprising an inhibitor of H3K27 methylation, methods of predicting responsiveness of a patient having a cancer to treatment comprising one or more inhibitors of H3K27 methylation, methods of selecting a therapy for a patient having a cancer, and methods of treating cancer based on expression levels of biomarkers of the invention (e.g., the expression level of SMARCA2 or the occupancy level of H3K27 at a SMARCA2 promoter).