公开(公告)号：US08765131B2

公开(公告)日：2014-07-01

申请号：US13759743

申请日：2013-02-05

申请人： Genentech, Inc.

发明人： Michael Fung ,  William N. C. Sun ,  Cecily R. Y. Sun

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K16/36

CPC分类号： C07K16/40 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/76

摘要： The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, F(ab′)2 and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds. A monoclonal antibody which bound to factor D and blocked its ability to activate complement was generated and designated 166-32. The hybridoma producing this antibody was deposited at the American Type Culture Collection, 10801 University Blvd., Manassas, Va. 20110-2209, under Accession Number HB-12476.

摘要翻译： 本发明涉及与因子D结合并阻断因子D在补体激活中的功能活性的因子D抑制剂。 抑制剂包括抗体分子，以及同系物，类似物及其修饰或衍生形式，包括免疫球蛋白片段如Fab，F（ab'）2和Fv，小分子，包括肽，寡核苷酸，肽模拟物和有机化合物。 产生与因子D结合并阻断其激活补体的能力的单克隆抗体，并命名为166-32。 产生该抗体的杂交瘤保藏在American Type Culture Collection，10801 University Blvd.，Manassas，Va。20110-2209，登录号HB-12476。

公开(公告)号：US20130230522A1

公开(公告)日：2013-09-05

申请号：US13759687

申请日：2013-02-05

申请人： GENENTECH, INC.

发明人： Michael Fung ,  Meisheng Lu ,  William N. C. Sun ,  Cecily R. Y. Sun

IPC分类号： A61K39/395 ,  G01N33/68

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/569 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/6863 ,  G01N33/6893

摘要： The invention relates to inhibitors that bind to C5 and C5a, but which do not prevent the activation of C5 and do not prevent formation of or inhibit the activity of C5b. One example of such an inhibitor molecule is the monoclonal antibody designated MAb137-26, which binds to a shared epitope of human C5 and C5a. These inhibitors may be used to inhibit the activity of C5a in treating diseases and conditions mediated by excessive or uncontrolled production of C5a. The inhibitor molecules are also useful for diagnostic detection of the presence/absence or amount of C5 or C5a.

摘要翻译： 本发明涉及结合C5和C5a但不阻止C5活化且不阻止C5b活性的抑制剂。 这种抑制剂分子的一个实例是命名为MAb137-26的单克隆抗体，其结合人C5和C5a的共享表位。 这些抑制剂可用于抑制C5a在治疗由过量或不受控制的C5a产生介导的疾病和病症中的活性。 抑制剂分子也可用于诊断检测C5或C5a的存在/不存在或量。

公开(公告)号：US08907072B2

公开(公告)日：2014-12-09

申请号：US13759687

申请日：2013-02-05

申请人： Genentech, Inc.

发明人： Michael Fung ,  Meisheng Lu ,  William N. C. Sun ,  Cecily R. Y. Sun

IPC分类号： C12N15/13 ,  C12N15/12 ,  C12N15/10 ,  C12N5/10 ,  C07K16/18 ,  A61K39/395 ,  G01N33/68 ,  A61K39/00

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/569 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/6863 ,  G01N33/6893

摘要： The invention relates to inhibitors that bind to C5 and C5a, but which do not prevent the activation of C5 and do not prevent formation of or inhibit the activity of C5b. One example of such an inhibitor molecule is the monoclonal antibody designated MAb137-26, which binds to a shared epitope of human C5 and C5a. These inhibitors may be used to inhibit the activity of C5a in treating diseases and conditions mediated by excessive or uncontrolled production of C5a. The inhibitor molecules are also useful for diagnostic detection of the presence/absence or amount of C5 or C5a.

摘要翻译： 本发明涉及结合C5和C5a但不阻止C5活化且不阻止C5b活性的抑制剂。 这种抑制剂分子的一个实例是命名为MAb137-26的单克隆抗体，其结合人C5和C5a的共享表位。 这些抑制剂可用于抑制C5a在治疗由过量或不受控制的C5a产生介导的疾病和病症中的活性。 抑制剂分子也可用于诊断检测C5或C5a的存在/不存在或量。